Low methylation levels of the SFRP1 gene are associated with the basal-like subtype of breast cancer.

@article{Jeong2013LowML,
  title={Low methylation levels of the SFRP1 gene are associated with the basal-like subtype of breast cancer.},
  author={Young Ju Jeong and H-Y Jeong and Jin gu Bong and Sung Hwan Park and Hoon Kyu Oh},
  journal={Oncology reports},
  year={2013},
  volume={29 5},
  pages={
          1946-54
        }
}
Epigenetic analyses have shown that aberrant DNA methylation signatures are associated with breast cancer molecular subtypes. In this study, we analyzed the methylation status of breast cancer-related genes in relation to the molecular subtypes and investigated whether the basal-like subtype displays distinct methylation profiles. By using pyrosequencing, we analyzed the DNA methylation status of 5 candidate genes in 60 breast cancer samples. We compared the methylation frequency across the… 

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