Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries.

@article{Wiggers2008LowMC,
  title={Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries.},
  author={Giulia Alessandra Wiggers and Franck Maciel Peçanha and Ana Mar{\'i}a Briones and Jos{\'e} V P{\'e}rez-Gir{\'o}n and Maria Inez R. Miguel and Dalton Valentin Vassallo and Victoria Cachofeiro and Mar{\'i}a Jes{\'u}s Alonso and Mercedes Sala{\'i}ces},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 3},
  pages={H1033-H1043}
}
Increased cardiovascular risk after mercury exposure has been described, but the underlying mechanisms are not well explored. We analyzed the effects of chronic exposure to low mercury concentrations on endothelium-dependent responses in aorta and mesenteric resistance arteries (MRA). Wistar rats were treated with mercury chloride (1st dose 4.6 microg/kg, subsequent dose 0.07 microg.kg(-1).day(-1) im, 30 days) or vehicle. Blood levels at the end of treatment were 7.97 +/- 0.59 ng/ml. Mercury… CONTINUE READING

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