Low magnitude transformation of estradiol to estrone in human endometrium.

@article{Sweat1973LowMT,
  title={Low magnitude transformation of estradiol to estrone in human endometrium.},
  author={M. L. Sweat and R. Young},
  journal={Biochimica et biophysica acta},
  year={1973},
  volume={296 1},
  pages={
          189-95
        }
}
  • M. L. Sweat, R. Young
  • Published 1973
  • Chemistry, Medicine
  • Biochimica et biophysica acta
    • Abstract 1. 1. The human endometrium estradiol dehydrogenase has been shown to function at magnitudes significantly lower than those in which estradiol binding has been examined. Quantities as low as 0.0075 fmole have been shown to be transformed to 0.006 fmole of estione in 1 min by 1 mg of tissue. 2. 2. In sonicated preparations, transformation of estradiol to estrone is enhanced by NAD + and NADP + . NADPH does not influence the reverse reaction. 3. 3. The dehydrogenase appears to be cold… CONTINUE READING
    View on PubMed
    doi.org
    7 Citations

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    7 Citations
    Citation Type

    Citation Type

    Induction of estradiol dehydrogenase activity in human uterine endometrium by synthetic steroids
    • 11
    Metabolism of estradiol-17 in human endometrium during the menstrual cycle
    • 63
    Metabolism of oestradiol-1β in the human myometrium
    • 6
    Studies on the activity of 17 beta-hydroxysteroid dehydrogenase in human adipose tissue.
    • 16
    Inhibition of 17 beta-hydroxysteroid dehydrogenase activity in human endometrium by adrenal androgens.
    • 35
    Foam cells and estrogen activity of the human endometrium
    • 5
    The influence of synthetic anti-estrogens on the binding of tritiated estradiol-17beta by cytosols of human uterus and human breast carcinoma.
    • 48

    References

    SHOWING 1-10 OF 14 REFERENCES
    Metabolism of 17β-Estradiol and Estrone by Human Proliferative Endometrium and Myometrium1
    • 19
    The synthesis and metabolism of progesterone in the human and bovine ovary.
    • 54
    Glucose-6-phosphate dehydrogenase activity in the endometrium and myometrium of the rat uterus during the estrous cycle and progestation.
    • 10
    • PDF
    Eli Lilly Lecture: Estrogen Metabolism and Action1
    • 7
    Monomer-trimer transition of human placenta estradiol dehydrogenase.
    • D. Hagerman
    • Chemistry, Medicine
    • Archives of biochemistry and biophysics
    • 1969
    • 13
    Studies on steroid metabolism in human endometrial tissue.
    • 33
    • PDF
    Human placental 17 beta-estradiol dehydrogenase. VI. Substrate specificity of the diphosphopyridine nucleotide (triphosphopyridine nucleotide)-linked enzyme.
    • 18
    Estrogen receptors in the rat uterus. Studies on the interaction of cytosol and nuclear binding sites.
    • 227
    The subunit structure of human placental 17 -estradiol dehydrogenase.
    • 30
    Paper Chromatography of Phenolic Substances
    • 325