Low magnitude transformation of estradiol to estrone in human endometrium.

  title={Low magnitude transformation of estradiol to estrone in human endometrium.},
  author={M. L. Sweat and R. Young},
  journal={Biochimica et biophysica acta},
  volume={296 1},
  • M. L. Sweat, R. Young
  • Published 1973
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • Abstract 1. 1. The human endometrium estradiol dehydrogenase has been shown to function at magnitudes significantly lower than those in which estradiol binding has been examined. Quantities as low as 0.0075 fmole have been shown to be transformed to 0.006 fmole of estione in 1 min by 1 mg of tissue. 2. 2. In sonicated preparations, transformation of estradiol to estrone is enhanced by NAD + and NADP + . NADPH does not influence the reverse reaction. 3. 3. The dehydrogenase appears to be cold… CONTINUE READING
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