Low lung volume alters contractile properties of airway smooth muscle in sheep.

@article{McClean2003LowLV,
  title={Low lung volume alters contractile properties of airway smooth muscle in sheep.},
  author={Melissa A McClean and Michael E. Matheson and Kelly A Chiffer McKay and Peter A. Johnson and A C Rynell and Alaina J Ammit and J. L. Black and Norbert Berend},
  journal={The European respiratory journal},
  year={2003},
  volume={22 1},
  pages={
          50-6
        }
}
Breathing at volumes lower than functional residual capacity (FRC) can induce changes in nonasthmatic airways consistent with the behaviour of asthmatic airways. This study investigated the chronic effect of breathing at volumes lower than FRC on the contractility of airway smooth muscle and myosin light chain kinase (MLCK) content and activity. Sheep of three age groups (neonate, adolescent and adult) had their FRC reduced by approximately 25%, for 4 weeks using a leather corset. Contractile… CONTINUE READING

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