Low load for disruptive mutations in autism genes and their biased transmission

  title={Low load for disruptive mutations in autism genes and their biased transmission},
  author={Ivan Iossifova and Dan Levya and Jeremy Allena and Kenny Yec and Michael Ronemusa and Yoon-ha Leea and Boris Yamroma and Michael Wiglera},
  • Ivan Iossifova, Dan Levya, +5 authors Michael Wiglera
  • Published 2015
We previously computed that genes with de novo (DN) likely gene-disruptive (LGD) mutations in children with autism spectrum disorders (ASD) have high vulnerability: disruptive mutations in many of these genes, the vulnerable autism genes, will have a high likelihood of resulting in ASD. Because individuals with ASD have lower fecundity, such mutations in autism genes would be under strong negative selection pressure. An immediate prediction is that these genes will have a lower LGD load than… CONTINUE READING
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