Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle.

Abstract

OBJECTIVE We have previously demonstrated that activation of toll-like receptor 4 (TLR4) in skeletal muscle results in an increased reliance on glucose as an energy source and a concomitant decrease in fatty acid oxidation under basal conditions. Herein, we examined the effects of lipopolysaccharide (LPS), the primary ligand for TLR4, on mitochondrial… (More)
DOI: 10.1016/j.metabol.2014.11.007

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