Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness.

@article{Biggee2006LowLO,
  title={Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness.},
  author={Beth Anne Biggee and Christina M Blinn and Timothy E. McAlindon and Melynn Nuite and Jeremiah E. Silbert},
  journal={Annals of the rheumatic diseases},
  year={2006},
  volume={65 2},
  pages={222-6}
}
BACKGROUND Oral glucosamine preparations are widely used as a treatment for osteoarthritis, purportedly functioning by a variety of mechanisms suggested by results of in vitro experiments, and generally using glucosamine concentrations well in excess of 100 micromol/l. OBJECTIVE To use high performance liquid chromatography with a high sensitivity Metrohm-Peak instrument for pulsed amperometric measurement of human serum glucosamine; a detection limit of 0.5 micromol/l at 1:10 serum dilution… CONTINUE READING