Low levels of cadmium chloride damage the corneal endothelium

  title={Low levels of cadmium chloride damage the corneal endothelium},
  author={W. J. Weidner and A. Sillman},
  journal={Archives of Toxicology},
  • W. J. Weidner, A. Sillman
  • Published 1997
  • Chemistry, Medicine
  • Archives of Toxicology
  • The effect of cadmium chloride on the integrity of the endothelium of isolated bullfrog (Rana catesbeiana) corneas was examined by spectrophotometric analysis of corneal uptake of the vital stain Janus green and by scanning electron microscopy (SEM). The uptake of Janus green by the endothelium was dose related between 1.0 and 100.0 μM CdCl2. The effect of cadmium was significantly attenuated by the calcium channel blocker SKF 96365 and was augmented by the calcium ionophore A23187, indicating… CONTINUE READING
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