Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways.

@article{Barchowsky1999LowLO,
  title={Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways.},
  author={Aaron Barchowsky and Robert R Roussel and Linda R. Klei and Philip E. James and Neema Ganju and Kevin R. Smith and Edward J Dudek},
  journal={Toxicology and applied pharmacology},
  year={1999},
  volume={159 1},
  pages={65-75}
}
Chronic human exposure to low levels of inorganic arsenic increases the incidence of vascular diseases and specific cancers. Exposure of endothelial cells to environmentally relevant concentrations of arsenic trioxide (arsenite) induces oxidant formation, activates the transcription factor NF-kappaB, and increases DNA synthesis (Barchowsky et al., Free Radic. Biol. Med. 21, 783-790, 1996). We show, in the current study, that arsenite induces concentration-dependent cell proliferation or death… CONTINUE READING
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