Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks

@inproceedings{Rybak2016LowLP,
  title={Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks},
  author={Paulina Rybak and Agnieszka Hoang and Lukasz Bujnowicz and Tytus Bernaś and Krzysztof Berniak and Mirosław A Zarebski and Zbigniew Darzynkiewicz and Jerzy W. Dobrucki},
  booktitle={Oncotarget},
  year={2016}
}
Phosphorylation of histone H2AX on serine 139 (γH2AX) is an early step in cellular response to a DNA double-strand break (DSB). γH2AX foci are generally regarded as markers of DSBs. A growing body of evidence demonstrates, however, that while induction of DSBs always brings about phosphorylation of histone H2AX, the reverse is not true - the presence of γH2AX foci should not be considered an unequivocal marker of DNA double-strand breaks. We studied DNA damage induced in A549 human lung… CONTINUE READING

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