Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets.

@article{Song2012LowlevelPE,
  title={Low-level phenolic estrogen pollutants impair islet morphology and β-cell function in isolated rat islets.},
  author={Liqiong Song and Wei Xia and Zhao Zhou and Yuanyuan Li and Yi Lin and Jie Wei and Zhengzheng Wei and Bin Xu and Jie Shen and Weiyong Li and Shun-qing Xu},
  journal={The Journal of endocrinology},
  year={2012},
  volume={215 2},
  pages={303-11}
}
Phenolic estrogen pollutants, a class of typical endocrine-disrupting chemicals, have attracted public attention due to their estrogenic activities of imitating steroid hormone 17β-estradiol (E(2)) effects. Exposure to these pollutants may disrupt insulin secretion and be a risk factor for type 2 diabetes. In this study, we investigated the direct effects of phenolic estrogen diethylstilbestrol (DES), octylphenol (OP), nonylphenol (NP), and bisphenol A (BPA) on rat pancreatic islets in vitro… CONTINUE READING