Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.

@article{Volkow2001LowLO,
  title={Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.},
  author={Nora D. Volkow and Linda Chang and G J Wang and Joanna S. Fowler and Yu-Shin Ding and Margareta Sedler and Jean Logan and Dinko Franceschi and John S Gatley and Robert J. Hitzemann and Andrew N. Gifford and Christopher T Wong and Naomi R. Pappas},
  journal={The American journal of psychiatry},
  year={2001},
  volume={158 12},
  pages={2015-21}
}
OBJECTIVE The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the orbitofrontal cortex. Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study… CONTINUE READING
Highly Influential
This paper has highly influenced 30 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 296 extracted citations

Similar Papers

Loading similar papers…