Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.

@article{Wright2005LowLM,
  title={Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.},
  author={Caroline M Wright and O F Dent and Ronald C. Newland and Mandy Barker and Pierre H. Chapuis and E. Leslie Bokey and Joanne P. Young and Barbara A. Leggett and Jeremy R. Jass and Graeme A. Macdonald},
  journal={Gut},
  year={2005},
  volume={54 1},
  pages={103-8}
}
BACKGROUND Colorectal cancers (CRCs) may be categorised according to the degree of microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS). MSI-H status confers a survival advantage to patients with sporadic CRC. AIMS To determine if low levels of MSI are related to the clinicopathological features and prognosis of sporadic stage C CRC. PATIENTS A total of 255 patients who underwent resection for sporadic stage C CRC were studied. No… CONTINUE READING