Low level laser therapy increases angiogenesis in a model of ischemic skin flap in rats mediated by VEGF, HIF-1α and MMP-2.

@article{Cury2013LowLL,
  title={Low level laser therapy increases angiogenesis in a model of ischemic skin flap in rats mediated by VEGF, HIF-1α and MMP-2.},
  author={Vivian Cury and Ana Iochabel Soares Moretti and Livia L Assis and Paulo S{\'e}gio Bossini and Jaqueline de Souza Crusca and Carlos Benatti Neto and Renan Fangel and Heraldo Possolo de Souza and Michael R Hamblin and Nivaldo Antonio Parizotto},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2013},
  volume={125},
  pages={164-70}
}
It is known that low level laser therapy is able to improve skin flap viability by increasing angiogenesis. However, the mechanism for new blood vessel formation is not completely understood. Here, we investigated the effects of 660 nm and 780 nm lasers at fluences of 30 and 40 J/cm(2) on three important mediators activated during angiogenesis. Sixty male Wistar rats were used and randomly divided into five groups with twelve animals each. Groups were distributed as follows: skin flap surgery… CONTINUE READING

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