Low-level detection of viral pathogens by a surface-enhanced Raman scattering based immunoassay.

@article{Driskell2005LowlevelDO,
  title={Low-level detection of viral pathogens by a surface-enhanced Raman scattering based immunoassay.},
  author={Jeremy D. Driskell and Karen M Kwarta and Robert J. Lipert and Marc D. Porter and John D. Neill and Julia F. Ridpath},
  journal={Analytical chemistry},
  year={2005},
  volume={77 19},
  pages={6147-54}
}
The need for rapid, highly sensitive, and versatile diagnostic tests for viral pathogens spans from human and veterinary medicine to bioterrorism prevention. As an approach to meet these demands, a diagnostic test employing monoclonal antibodies (mAbs) for the selective extraction of viral pathogens from a sample in a chip-scale, sandwich immunoassay format has been developed using surface-enhanced Raman scattering (SERS) as a readout method. The strengths of SERS-based detection include its… CONTINUE READING

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