Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial.

@article{Augenlicht1997LowlevelCA,
  title={Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial.},
  author={Leonard H. Augenlicht and Scott S Wadler and Georgia A. Corner and Carolyn Richards and Lynn Ryan and Asha S Multani and Sen Pathak and A W Benson and Dirk Haller and Barbara G. Heerdt},
  journal={Cancer research},
  year={1997},
  volume={57 9},
  pages={1769-75}
}
Human colonic cancer is associated with multiple genetic deletions, mutations, and alterations in gene expression; in contrast, gene amplification has not been recognized as a prominent characteristic of human colonic tumors. Although the c-myc gene is overexpressed in approximately 70% of human colonic cancers, previous studies have not detected frequent gene amplification or rearrangement of c-myc in these tumors, although such amplification has been reported in chemically induced rodent… CONTINUE READING

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