Low level Pb(2+) exposure affects hippocampal protein kinase C gamma gene and protein expression in rats.

@article{Nihei2001LowLP,
  title={Low level Pb(2+) exposure affects hippocampal protein kinase C gamma gene and protein expression in rats.},
  author={M K Nihei and Jennifer L. McGlothan and Christopher D. Toscano and Tom{\'a}s R. Guilarte},
  journal={Neuroscience letters},
  year={2001},
  volume={298 3},
  pages={212-6}
}
We examined the effect of chronic exposure to lead (Pb(2+)) on protein kinase C (PKC) in 50-day-old rat hippocampus. Cytosolic and membrane fractions of hippocampus from Pb(2+)-exposed rats showed reduced expression of PKC gamma protein. In contrast, a significant elevation of PKC gamma mRNA was observed in pyramidal and dentate granule cell layers. Protein expression of alpha, beta I, beta II and epsilon isoenzymes were unchanged in Pb(2+)-exposed rats, as was [(3)H]phorbol 12,13 dibutyrate… CONTINUE READING

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