Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants.

@article{Jackman2013LowlevelHA,
  title={Low-level HLA antibodies do not predict platelet transfusion failure in TRAP study participants.},
  author={Rachael P Jackman and Xutao Deng and Douglas D Bolgiano and Marina Petrovna Lebedeva and John W. Heitman and Michael P. Busch and Sherrill J. Slichter and Phillip J Norris},
  journal={Blood},
  year={2013},
  volume={121 16},
  pages={
          3261-6; quiz 3299
        }
}
In the Trial to Reduce Alloimmunization to Platelets (TRAP) study, 101 of 530 participants became refractory to platelet transfusions without evidence of HLA or human platelet antigen (HPA) antibodies. We used a more sensitive bead-based assay to detect and quantify HLA antibodies and a qualitative solid-phase enzyme-linked immunosorbet assay for HPA to determine whether low-level antibodies could predict refractoriness in longitudinal panels from 170 lymphocytotoxicity assay (LCA)(-) and 20… CONTINUE READING

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