Low leukocyte counts with blast cells in cerebrospinal fluid of children with newly diagnosed acute lymphoblastic leukemia.

@article{Mahmoud1993LowLC,
  title={Low leukocyte counts with blast cells in cerebrospinal fluid of children with newly diagnosed acute lymphoblastic leukemia.},
  author={Hazem H Mahmoud and Gaston K. Rivera and Michael L. Hancock and Robert A. Krance and Larry E. Kun and Frederick G. Behm and Raul C. Ribeiro and John T. Sandlund and William M. Crist and Ching-Hon Pui},
  journal={The New England journal of medicine},
  year={1993},
  volume={329 5},
  pages={314-9}
}
BACKGROUND Treatment of the central nervous system is crucial to the successful treatment of acute lymphoblastic leukemia in children. The intensity and timing of the therapy are based on the presence or predicted risk of central nervous system leukemia as assessed according to criteria that remain controversial. METHODS The clinical importance of leukemic blast cells detected in cerebrospinal fluid at the time of diagnosis was evaluated in 351 children with acute lymphoblastic leukemia in a… CONTINUE READING
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