Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation.

@article{Brady2014LowIO,
  title={Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation.},
  author={Allison M Brady and Juan J. Calix and Jigui Yu and Kimball Aaron Geno and Gary R. Cutter and Moon H. Nahm},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={210 7},
  pages={1155-65}
}
BACKGROUND The divergent epidemiological behavior of Streptococcus pneumoniae serotypes suggests that serotype-specific features such as capsule O-acetylation influence the propensity of a strain to cause invasive pneumococcal disease (IPD). We hypothesize that innate host factors mediate the observed negative association between IPD and the serotype 11A… CONTINUE READING