Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.

@article{Bagher2012LowIP,
  title={Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone.},
  author={Pooneh Bagher and Timea Z Beleznai and Yasuo Kansui and Ray Mitchell and Christopher J Garland and Kim A Dora},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 44},
  pages={18174-9}
}
Endothelial cell (EC) Ca(2+)-activated K channels (SK(Ca) and IK(Ca) channels) generate hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation. IK(Ca) channels focused within EC projections toward the smooth muscle cells are activated by spontaneous Ca(2+) events (Ca(2+) puffs/pulsars). We now show that transient receptor potential, vanilloid 4 channels (TRPV4 channels) also cluster within this microdomain and are selectively activated at low intravascular… CONTINUE READING
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