Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity.

@article{Chicco2006LowintensityET,
  title={Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity.},
  author={Adam J. Chicco and David S. Hydock and Carole M. Schneider and Reid Hayward},
  journal={Journal of applied physiology},
  year={2006},
  volume={100 2},
  pages={
          519-27
        }
}
Doxorubicin (Dox) is a highly effective antineoplastic antibiotic associated with a dose-limiting cardiotoxicity that may result in irreversible cardiomyopathy and heart failure. The purpose of this study was to examine the effects of low-intensity exercise training (LIET) during the course of Dox treatment on cardiac function, myosin heavy chain expression, oxidative stress, and apoptosis activation following treatment. Male Sprague-Dawley rats either remained sedentary or were exercise… 

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