Low-inoculum model of surgical wound infection.

  title={Low-inoculum model of surgical wound infection.},
  author={Allen B. Kaiser and Douglas S. Kernodle and Robert A. Parker},
  journal={The Journal of infectious diseases},
  volume={166 2},
A model of surgical wound infection that uses low inocula of bacteria and closely simulates clinical infection involved inoculating suspensions of Staphylococcus aureus and dextran microbeads into intermuscular sites on the dorsum of guinea pigs, harvesting lesions at 72-96 h, identifying as a positive end point lesions yielding staphylococci on subculture, and using logistic regression for data analysis. Prophylaxis was placebo, ampicillin, or cefazolin, and three representative strains of S… CONTINUE READING

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