Low incidence of ototoxicity with continuous infusion of cisplatin in the treatment of pediatric germ cell tumors.

@article{Gupta2006LowIO,
  title={Low incidence of ototoxicity with continuous infusion of cisplatin in the treatment of pediatric germ cell tumors.},
  author={Abha A Gupta and Michael E Capra and Vicky Papaioannou and Gillian Hall and Ronnen Maze and David Dix and Shimon Weitzman},
  journal={Journal of pediatric hematology/oncology},
  year={2006},
  volume={28 2},
  pages={
          91-4
        }
}
Cisplatin is an important chemotherapeutic agent in the treatment of many pediatric malignancies, but its use is limited in part by ototoxicity. The authors' institution has been administering standard-dose cisplatin by continuous infusion rather than bolus administration in germ cell tumors. The authors retrospectively reviewed 39 patients with germ cell tumors requiring chemotherapy over the past 20 years and recorded data including demographics, cumulative cisplatin dose, degree of… CONTINUE READING
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