Low immunoglobulin E flags two distinct types of immune dysregulation.

@article{Elkuch2017LowIE,
  title={Low immunoglobulin E flags two distinct types of immune dysregulation.},
  author={M Elkuch and Victor Greiff and Christoph T Berger and M Bouchenaki and Thomas D Daikeler and Andreas J Bircher and Alexander Navarini and Ingmar A. F. M. Heijnen and Mike Recher},
  journal={Clinical and experimental immunology},
  year={2017},
  volume={187 3},
  pages={
          345-352
        }
}
During the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a… CONTINUE READING
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