Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters

Abstract

Efflux transporters like MDR1 and MRP2 may modulate the pharmacokinetics of about 50 % of all drugs. It is currently unknown how much of the variation in the activities of important drug membrane transporters like MDR1 or MRP2 is determined by genetic or by environmental factors. In this study we assessed the heritability of the pharmacokinetics of… (More)
DOI: 10.1186/s13073-016-0372-2

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@inproceedings{Matthaei2016LowHI, title={Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters}, author={Johannes Matthaei and Mladen Vassilev Tzvetkov and Valerie Gal and Cordula Sachse-Seeboth and Daniel B Sehrt and Jakob B Hjelmborg and Ute Hofmann and Matthias Schwab and Reinhold Kerb and J{\"{u}rgen Brockm{\"{o}ller}, booktitle={Genome Medicine}, year={2016} }