Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia.

@article{Pietrini1997LowGM,
  title={Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia.},
  author={Pietro Pietrini and Anis Dani and Maura L. Furey and Gene E. Alexander and Ulderico Freo and Cheryl L. Grady and Marc J Mentis and D. J. Mangot and Elliott W. Simon and Barry Horwitz and James V. Haxby and Mark B. Schapiro},
  journal={The American journal of psychiatry},
  year={1997},
  volume={154 8},
  pages={1063-9}
}
OBJECTIVE Down's syndrome is characterized by the genetically programmed accumulation of substantial Alzheimer's disease neuropathology after age 40 and the development of early dementia years later, providing a unique human model to investigate the preclinical phases of Alzheimer's disease. Older nondemented adults with Down's syndrome show normal rates of regional cerebral glucose metabolism at rest before the onset of dementia, indicating that their neurons maintain function at rest. The… CONTINUE READING
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