Low glucose-6-phosphate dehydrogenase activity and increased sensitivity to paraquat toxicity

  title={Low glucose-6-phosphate dehydrogenase activity and increased sensitivity to paraquat toxicity},
  author={Edward J. Calabrese and Gary S. Moore and S C Ho},
  journal={Bulletin of Environmental Contamination and Toxicology},
13 Citations
Screening for potential hemolytic responses to environmental agents using a bioactivation system: Evaluation of six pesticides
The results indicated that the parent compounds of all the pesticides and the metabolites of all pesticides except diuron were not oxldant stressor agents towards G‐6‐PD deficient erythrocytes, in vitro.
Attempts to validate a possible predictive animal model for human erythrocyte G‐6‐PD deficiency
The results indicated that metabolites of the Pharmaceuticals, B‐naphthol, dapsone, and sulfanilamide, are oxidant, which agreed with studies on the response of human G‐6‐PD deficient erythrocytes.
Use of a bioactivation system to screen for hemolytic response to environmental agents: Evaluation of six pesticides
The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes, in vitro.
Predictive models for human glucose-6-phosphate dehydrogenase deficiency.
The present paper has discussed available test systems for determination of the response of G-6-PD-deficient human erythrocytes to environmental agents and the results of research using each model have been presented.
Toxicity of aromatic disulphides. II. Intra‐erythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides
  • R. Munday
  • Biology, Chemistry
    Journal of applied toxicology : JAT
  • 1985
Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of
Effect ofin vivo ozone exposure to dorset sheep, an animal model with low levels of erythrocyte glucose-6-phosphate dehydrogenase activity
  • G. Moore, E. Calabrese, E. Schulz
  • Biology, Environmental Science
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 1984
Female Dorset sheep were exposed in vivo to ambient ozone levels and the effects of this exposure upon erythrocytes were studied, showing biochemical evidence of oxidant stress as indicated by decreases in GSH levels and ACHE and increases in MetHb.
Studies on the mechanism of toxicity of the mycotoxin sporidesmin. 2—evidence for intracellular generation of superoxide radical from sporidesmin
  • R. Munday
  • Biology
    Journal of applied toxicology : JAT
  • 1984
The erythrocytic changes induced by the mycotoxin, which are characteristically produced by compounds which generate ‘active oxygen’ species, suggest that it is also capable of generating this radical intracellularly.


Hematology: Principles and Procedures
Part 1 Basic laboratory techniques: composition of blood universal precautions collection of blood anticoagulants the microscope photometer/spectrophotometer centrifugation statistical tools used to
Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.
Oxygen-tolerant rats, which increased activities of pulmonary enzymes which combat lipid peroxidation, were also tolerant to lethal doses of paraquat as indicated by an increased paraquats LT50, and rats chronically exposed to 100 ppm paraqu at in the water had elevated pulmonary activities of glucose-6-phosphate dehydrogenase and GSH reductase.