Low glucose-6-phosphate dehydrogenase (G-6-PD) activity in red blood cells and susceptibility to copper-induced oxidative damage.

  title={Low glucose-6-phosphate dehydrogenase (G-6-PD) activity in red blood cells and susceptibility to copper-induced oxidative damage.},
  author={Edward J. Calabrese and Gary S. Moore and S C Ho},
  journal={Environmental research},
  volume={21 2},
Predictive models for human glucose-6-phosphate dehydrogenase deficiency.
The present paper has discussed available test systems for determination of the response of G-6-PD-deficient human erythrocytes to environmental agents and the results of research using each model have been presented.
A model in vitro system for assessing the effects of oxidant stressor agents on red cells with chemically‐induced superoxide dismutase deficiency
Abstract An in vitro test system was established to determine the oxidant Stressor effects of various agents on erythrocytes having low Superoxide dismutase (SOD) activity. The compound,
An evaluation of the dorset sheep as a predictive animal model for the response of G-6-PD deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl oleate hydroperoxide.
The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD deficient ery Throcytes to MOHP that seriously questions the value of the sheep ERYthrocyte as a quantitatively accurate predictive model.
The effects of ascorbic acid on copper‐induced oxidative changes in human erythrocytes: Example of a biphasic dose‐response relationship
In an in vitro study, ascorbic acid reduced the occurrence of copper acetate‐induced oxidative stress in human erythrocytes at biologically relevant concentrations while enhancing oxidative changes at higher levels of exposure.
Molecular study of ovine glucose 6-phosphate dehydrogenase gene expression in respect to different energy intake.
Use of a bioactivation system to screen for hemolytic response to environmental agents: Evaluation of six pesticides
The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes, in vitro.


The effect of copper on red cell enzyme activities.
The inhibition of red cell enzymes by copper was completely reversed by the addition of EDTA.
  • E. Beutler
  • Biology, Medicine
    British journal of haematology
  • 1970
In the past two decades studies on abnormal haemoglobins have made great strides possible in the understanding of human biology. in recent years, the investigations of workers all over the world have
Chronic copper poisoning in sheep. I. The relationship of methaemoglobinemia to Heinz body formation and haemolysis during the terminal crisis.
It is concluded that the methaemoglobin formation is mainly an intra-corpuscular process and that most of the met Haemoglobin detected in plasma in chronic copper poisoning in sheep, comes from the erythrocytes.
Ozone: a possible cause of hemolytic anemia in glucose-6-phosphate dehydrogenase deficient individuals.
A theoretical model is described that predicts that individuals with a glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis on exposure to ozone at levels reached in certain
Prostaglandins and their effects on human placental adenyl cyclase.
  • K. Satoh, K. Ryan
  • Biology, Medicine
    The Journal of clinical investigation
  • 1972
Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.
Hematology: Principles and Procedures
Part 1 Basic laboratory techniques: composition of blood universal precautions collection of blood anticoagulants the microscope photometer/spectrophotometer centrifugation statistical tools used to