Low-frequency oscillations in the cerebellar cortex of the tottering mouse.

@article{Chen2009LowfrequencyOI,
  title={Low-frequency oscillations in the cerebellar cortex of the tottering mouse.},
  author={G. W. Chen and Laurentiu S. Popa and Xinming Wang and Wangcai Gao and Justin A Barnes and Claudia M. Hendrix and Ellen J Hess and Timothy J Ebner},
  journal={Journal of neurophysiology},
  year={2009},
  volume={101 1},
  pages={234-45}
}
The tottering mouse is an autosomal recessive disorder involving a missense mutation in the gene encoding P/Q-type voltage-gated Ca2+ channels. The tottering mouse has a characteristic phenotype consisting of transient attacks of dystonia triggered by stress, caffeine, or ethanol. The neural events underlying these episodes of dystonia are unknown. Flavoprotein autofluorescence optical imaging revealed transient, low-frequency oscillations in the cerebellar cortex of anesthetized and awake… CONTINUE READING