Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.

@article{Ikuta1985LowFO,
  title={Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.},
  author={Kazuyoshi Ikuta and Teru Ogura and Akira Shimizu and T. Honjo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 22},
  pages={7701-5}
}
We have cloned three pairs of rearranged and germ-line variable region (V beta) genes of the beta chain of the human T-cell receptor from the cell lines ATL2, ATL12, and MT-1 of patients with adult T-cell leukemia (ATL). The pairs were derived from the same (for ATL2 and ATL12) and different (for MT-1) individuals. Comparison of the nucleotide sequences showed no somatic mutation in V beta X ATL2 and beta X ATL12-2. Although one nucleotide change was found in V beta X MT1-1, the possibility of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
40 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…