Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.

@article{Vatan2007LowFO,
  title={Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.},
  author={Ozgur Vatan and Rahmi Bilaloğlu and Berrin Tunca and Gulsah Cecener and Cengiz Gebitekin and Unal Egeli and Tahsin Yakut and Nur Urer},
  journal={Tumori},
  year={2007},
  volume={93 5},
  pages={473-7}
}
AIMS AND BACKGROUND Lung cancer is one of the most common cancers and has became a predominant cause of cancer-related death throughout the world. The k-ras codon 12 mutation, which is the most common lung cancer mutation, is found in 15 to 30% of all lung cancers. Furthermore, the p53 gene has a very important role in the biological properties of tumor cells, and it is mutated in about 50% of non-small cell lung cancers. Residual tumor cells remain in surgical margins diagnosed as tumor free… CONTINUE READING