Low frequency of imprinting defects in ICSI children born small for gestational age

@article{Kanber2009LowFO,
  title={Low frequency of imprinting defects in ICSI children born small for gestational age},
  author={Deniz Kanber and Karin Buiting and Michael Zeschnigk and M. Ludwig and Bernhard Horsthemke},
  journal={European Journal of Human Genetics},
  year={2009},
  volume={17},
  pages={22-29}
}
Although there is an increased frequency of low birth weight after assisted reproduction, the mechanisms underlying this association are unclear. We have proposed that some of the children conceived by intracytoplasmic sperm injection (ICSI) with low birth weight might have an epimutation (faulty methylation pattern) in one of the imprinted genes involved in fetal growth control, eg, KCNQ1OT1, PEG1, PEG3, GTL2, IGF2/H19 and PLAGL1. Using bisulfite DNA sequencing and sequence-based quantitative… CONTINUE READING
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