Low frequency of genetic change in p53 immunopositive clones in human epidermis.

@article{Tabata1999LowFO,
  title={Low frequency of genetic change in p53 immunopositive clones in human epidermis.},
  author={Hiroki Tabata and Tohru Nagano and Amanda J Ray and Niamh Flanagan and Mark A Birch-Machin and Jonathan Laurence Rees},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={113 6},
  pages={972-6}
}
Sun-exposed skin of Caucasians harbors thousands of p53-mutated clones, which are clinically invisible. Using whole mount immunostaining for p53 or Ki67 antigens, p53 sequencing, and loss of heterozygosity analysis, we have further characterised these clones. Loss of heterozygosity for the alleles examined is uncommon with the exception of 9q, which occurred in 28.3% of the samples. P53 clones are more common and larger in individuals with basal cell carcinoma than in control subjects (p < 0.03… CONTINUE READING

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