Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin's lymphoma.


Reed-Sternberg (RS) cells, the neoplastic elements of Hodgkin's lymphoma (HL), usually lack B-cell receptor expression. Normal germinal center B cells, with lack of or low-affinity B-cell receptor expression, are eliminated via FAS-induced apoptosis. RS cells express FAS, but are rescued from apoptosis by a transforming event. It is known that HL-derived… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.