Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations.

@article{Zheng2006LowfrequencyNM,
  title={Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations.},
  author={Wenjun Zheng and Bernard R. Brooks and D. Thirumalai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 20},
  pages={7664-9}
}
By representing the high-resolution crystal structures of a number of enzymes using the elastic network model, it has been shown that only a few low-frequency normal modes are needed to describe the large-scale domain movements that are triggered by ligand binding. Here we explore a link between the nearly invariant nature of the modes that describe functional dynamics at the mesoscopic level and the large evolutionary sequence variations at the residue level. By using a structural perturbation… CONTINUE READING

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