Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations.


By representing the high-resolution crystal structures of a number of enzymes using the elastic network model, it has been shown that only a few low-frequency normal modes are needed to describe the large-scale domain movements that are triggered by ligand binding. Here we explore a link between the nearly invariant nature of the modes that describe… (More)


7 Figures and Tables