Low-frequency EPR detection of chromium(V) formation by chromium(VI) reduction in whole live mice.

@article{Liu1994LowfrequencyED,
  title={Low-frequency EPR detection of chromium(V) formation by chromium(VI) reduction in whole live mice.},
  author={Ke Jian Liu and Jimmy J Jiang and Harold M. Swartz and Xianglin Shi},
  journal={Archives of biochemistry and biophysics},
  year={1994},
  volume={313 2},
  pages={248-52}
}
Measurements by direct low frequency EPR spectroscopy provide the first evidence that Cr(V) is generated in one-electron reduction of Cr(VI) in live mice. The Cr(V) yield reached a maximum about 10 min following Cr(VI) intravenous injection and then decayed slowly with a life time of approximately 37 min. The time for the Cr(V) EPR signal to reach maximum intensity increased with the dose of Cr(VI). A discernible EPR signal was still observable at a dose as low as 0.1 mmol/kg. The Cr(V) was… CONTINUE READING

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