Low free testosterone is an independent risk factor for Alzheimer's disease

  title={Low free testosterone is an independent risk factor for Alzheimer's disease},
  author={E. Hogervorst and S. Bandelow and M. Combrinck and A. D. Smith},
  journal={Experimental Gerontology},
  • E. Hogervorst, S. Bandelow, +1 author A. D. Smith
  • Published 2004
  • Medicine, Biology
  • Experimental Gerontology
  • The purpose of this study was to assess pituitary gonadotropins and free testosterone levels in a larger cohort of men with Alzheimer's disease (AD, n=112) and age-matched controls (n=98) from the Oxford Project to Investigate Memory and Ageing (OPTIMA). We measured gonadotropins (follicle stimulating hormone, FSH, and luteinizing hormone, LH), sex hormone binding globulin (SHBG, which determines the amount of free testosterone) and total testosterone (TT) using enzyme immunoassays. AD cases… CONTINUE READING
    156 Citations
    Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men.
    • 36
    • Highly Influenced
    P4-044: Sex hormone binding globulin and incident Alzheimer's disease in elderly men and women
    • 3


    Testosterone and gonadotropin levels in men with dementia.
    • 85
    • PDF
    Free testosterone and risk for Alzheimer disease in older men
    • 318
    • PDF
    Elevated gonadotropin levels in patients with Alzheimer disease.
    • 133
    An Association of Elevated Serum Gonadotropin Concentrations and Alzheimer Disease?
    • 137
    • Highly Influential
    Low androgenization index in elderly women and elderly men with Alzheimer’s disease
    • 79
    The influence of hyperthyroidism on the hypothalamic-pituitary-gonadal axis.
    • 34
    Variations of sex hormone-binding globulin in thyroid dysfunction.
    • 44
    Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men.
    • 373
    • PDF