Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells.

@article{Xue1997LowEP,
  title={Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells.},
  author={Liang-yan Xue and John Milton Lucocq},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={241 2},
  pages={
          236-42
        }
}
The mechanism by which mammalian cells respond to low environmental pH is unclear. A wide range of environmental stresses are known to induce activation of MAP kinases ERK 2, JNK and p38 and recent work has shown that low pH can activate the p38 homologue in yeast HOG1. In this study we show that ERK2 MAP kinase is activated in human A431 cells exposed to low pH media. Activation is sustained throughout low pH treatment, is reversible, and occurs maximally at pH 4 or 5. Stimulation is not… CONTINUE READING

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