Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity.


The glucocorticoid-induced leucine zipper (GILZ), a primary target of glucocorticoids, is expressed in human adipocytes, but its importance in adipocyte function is unknown. Because TNFα is increased in obese adipose tissue and antagonizes a number of glucocorticoid actions, we investigated the interplay of these pathways. GILZ knockdown increased and GILZ… (More)
DOI: 10.1194/jlr.M067728


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