Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN.

  title={Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN.},
  author={Chunxiang Lou and X-T Zhou and Qinggang Tian and H-Q Xie and J.-Y. Zhang},
  journal={European review for medical and pharmacological sciences},
  volume={22 19},
OBJECTIVE We investigate whether microRNA-21 could increase the infiltration ability of trophoblast cells via regulating PTEN expression, thus participating in the occurrence and development of preeclampsia. PATIENTS AND METHODS MicroRNA-21 expression in the placenta tissues of preeclampsia women and normal pregnant women was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The effects of microRNA-21 on cell proliferation and infiltration were examined by cell counting… 

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