Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN.

@article{Lou2018LowEO,
  title={Low expression of microRNA-21 inhibits trophoblast cell infiltration through targeting PTEN.},
  author={Chunxiang Lou and X-T Zhou and Qinggang Tian and H-Q Xie and J.-Y. Zhang},
  journal={European review for medical and pharmacological sciences},
  year={2018},
  volume={22 19},
  pages={
          6181-6189
        }
}
OBJECTIVE We investigate whether microRNA-21 could increase the infiltration ability of trophoblast cells via regulating PTEN expression, thus participating in the occurrence and development of preeclampsia. PATIENTS AND METHODS MicroRNA-21 expression in the placenta tissues of preeclampsia women and normal pregnant women was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The effects of microRNA-21 on cell proliferation and infiltration were examined by cell counting… 

Figures from this paper

miR-132 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability

TLDR
Investigation of the expression and diagnostic potential of microRNA-132 in GDM patients and the effects of miR-132 on HTR-8/SVneo cell proliferation revealed the reduced expression ofmiR- 132 in serum and placenta tissues of GDM, and serum mi R-132 serves a candidate biomarker in the diagnosis of G DM.

The Role of circRNA-SETD2/miR-519a/PTEN Axis in Fetal Birth Weight through Regulating Trophoblast Proliferation

TLDR
The role of circ-SETD2, as an upstream signaling of miR-519a/PTEN, in placenta development via regulating trophoblast proliferation and invasion is illustrated to improve the understanding of the mechanisms of progression of fetal macrosomia.

Preeclamptic Women Have Disrupted Placental microRNA Expression at the Time of Preeclampsia Diagnosis: Meta-Analysis

TLDR
Whether women with PE have disrupted miRNA expression compared to women who do not have PE is determined and the identification of differentially expressed miRNAs in maternal blood creates an opportunity to define an easily accessible biomarker of PE.

MicroRNAs in Uteroplacental Vascular Dysfunction

TLDR
An overview of how aberrant miRNA expression in preeclampsia and IUGR impacts the expression of genes involved in trophoblast invasion and uteroplacental vascular adaptation is provided.

(Dis)similarities between the Decidual and Tumor Microenvironment

TLDR
An overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate is provided, particularly focusing on the role of the abetting microenvironments.

Exosomal microRNA‐139‐5p from mesenchymal stem cells accelerates trophoblast cell invasion and migration by motivation of the ERK/MMP‐2 pathway via downregulation of protein tyrosine phosphatase

TLDR
This work has assessed the specific mechanism of mesenchymal stem cells (MSC)‐originated exosomes in PE and its role in systemic dysfunctions, including preeclampsia.

References

SHOWING 1-10 OF 28 REFERENCES

The expression significance of serum MiR-21 in patients with osteosarcoma and its relationship with chemosensitivity.

TLDR
The expression level of serum miR-21 in patients with osteosarcoma is closely related to the therapeutic effects of osteosARcoma, which can be used as one of the potential biomarkers and therapeutic targets for the diagnosis and prediction of ostea.

Placental Expression of miR-517a/b and miR-517c Contributes to Trophoblast Dysfunction and Preeclampsia

TLDR
It is demonstrated that miR-517a/b and miC-517c contribute to the development of preeclampsia and suggested that these miRNAs play a critical role in regulating trophoblast and placental function.

Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A

TLDR
A bioinformatic analysis showed that thrombospondin type I domain containing 7A (THSD7A) is a predicted target for miR-210, and novel data is provided on the function of TH SD7A in human placental cells, and knowledge of how microRNA-210 is involved in the development of the preeclampsia is extended.

MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies

TLDR
Results have shown that miR-210 and mi-155 were upregulated in serum of PE pregnancies, which suggest a potential association between these 2 miRNAs and the pathogenesis of PE.

Upregulation of miR-21 in Cisplatin Resistant Ovarian Cancer via JNK-1/c-Jun Pathway

TLDR
The results suggest that the JNK-1/c-Jun/miR-21 pathway contributes to the cisplatin resistance of ovarian cancer cells and demonstrated that miR- 21 is a plausible target to overcome cisPlatin resistance.

miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1

TLDR
It is found that miR-125b was deregulated in placental tissues and plasma derived from PE patients, which suggest a potential association between this miRNA and the pathogenesis of PE.

MicroRNA function in cancer: oncogene or a tumor suppressor?

TLDR
The importance of miRNAs in regulating cellular differentiation and proliferation is not surprising, and their misregulation is linked to cancer.

MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN

TLDR
MiR-21 and miR-155 promote the development of NSCLC, in part by downregulating SOCS1, SOCS6, and PTEN, three tumor suppressor genes often silenced inNSCLC.