Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition.

@article{Rodrigues2007LowEO,
  title={Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition.},
  author={Ananda Lages Rodrigues and Erica Patr{\'i}cia Garcia de Souza and Simone Vargas da Silva and Dayane S B Rodrigues and Aline B Nascimento and Christina Barja-Fidalgo and Marta Sampaio de Freitas},
  journal={The Journal of endocrinology},
  year={2007},
  volume={195 3},
  pages={485-94}
}
Experimental and clinical studies have demonstrated that early postnatal overnutrition represents a risk factor for later obesity and associated metabolic and cardiovascular disturbance. In the present study, we assessed the levels of glucose transporter 4 (GLUT-4), GLUT-1, insulin receptor (IR), IR substrate 1 (IRS-1), phosphatidylinositol 3-kinase (PI3K) and Akt expression, as well as insulin-stimulated glucose transport and Akt activity in adipocytes from adult rats previously raised in… CONTINUE READING