Low expression of RECK indicates a shorter survival for patients with invasive breast cancer.


Expression cloning was used to initially isolate the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene as a suppressor of transformation. The gene was found to encode a membrane-anchored regulator of MMPs. Experimental studies showed that RECK can suppress tumor invasion, metastasis, and angiogenesis. However, the clinical impact of… (More)
DOI: 10.1111/j.1349-7006.2012.02265.x


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