Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion.

Abstract

AIMS Tumour-infiltrating forkhead box P3 (FoxP3+ ) regulatory T cells (T(regs) ) have stronger prognostic significance than cytotoxic CD8+ T cells in colorectal cancer (CRC). Because there is evidence that some tumour-infiltrating CD8+ T cells may be inactive, the present study aimed to investigate the prognostic significance of Granzyme B, one of the major… (More)
DOI: 10.1111/j.1365-2559.2011.03915.x

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