Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma.

@article{Hwang2003LowEL,
  title={Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma.},
  author={C Hwang and C. -Y. Su and S Huang and Chao-Cheng Huang and Fu-Min Fang and Chun-Chung Lui and Hsueh-wen Chang and C Cho},
  journal={Cancer letters},
  year={2003},
  volume={189 2},
  pages={231-6}
}
To clarify the roles of p27 and c-myc in nasopharyngeal carcinoma (NPC), we used immunohistochemical studies to examine the expression of p27 and c-myc proteins in 69 patients with NPC. The results show that a low level of expression was observed in 47 and 41 cases, respectively. A low level of p27 expression was significantly correlated with loco-regional recurrence, and reduction in the c-myc protein was also correlated with neck metastasis in NPC. Our study indicates that a reduction in p27… CONTINUE READING