Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.

@article{Naassila2002LowES,
  title={Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.},
  author={Micka{\"e}l Naassila and Catherine A. Ledent and Martine Daoust},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 23},
  pages={10487-93}
}
We have shown previously that the severity of handling-induced convulsions during ethanol withdrawal was reduced in A2A receptor knock-out (A2AR-/-) mice. In the present report, we further characterize the role of adenosine A(2A) receptors in ethanol consumption and neurobiological responses to this drug of abuse. Male A2AR-/- mice showed increased consumption of solutions containing 6 and 20% (v/v) ethanol compared with wild-type (A2AR+/+) control mice; female A2AR-/- mice showed increased… CONTINUE READING