Low erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity and susceptibility to nitrite-induced methemoglobin formation

@article{Calabrese1980LowEG,
  title={Low erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity and susceptibility to nitrite-induced methemoglobin formation},
  author={Edward J. Calabrese and Gary S. Moore and S C Ho},
  journal={Bulletin of Environmental Contamination and Toxicology},
  year={1980},
  volume={25},
  pages={837-840}
}
14 Citations
Endogenous methemoglobinemia associated with diarrheal disease in infancy.
TLDR
For 12 years, there was a significant decrease in the annual incidence of methemoglobinemia associated with diarrhea in parallel to the decrease in infantile diarrhea due to known pathogens throughout the country in the same period.
Screening for potential hemolytic responses to environmental agents using a bioactivation system: Evaluation of six pesticides
TLDR
The results indicated that the parent compounds of all the pesticides and the metabolites of all pesticides except diuron were not oxldant stressor agents towards G‐6‐PD deficient erythrocytes, in vitro.
A model in vitro system for assessing the effects of oxidant stressor agents on red cells with chemically‐induced superoxide dismutase deficiency
Abstract An in vitro test system was established to determine the oxidant Stressor effects of various agents on erythrocytes having low Superoxide dismutase (SOD) activity. The compound,
Attempts to validate a possible predictive animal model for human erythrocyte G‐6‐PD deficiency
TLDR
The results indicated that metabolites of the Pharmaceuticals, B‐naphthol, dapsone, and sulfanilamide, are oxidant, which agreed with studies on the response of human G‐6‐PD deficient erythrocytes.
Use of a bioactivation system to screen for hemolytic response to environmental agents: Evaluation of six pesticides
TLDR
The pesticides, zineb and parathion, incubated without the microsomal enzyme system, did exert statistically significant oxidizing effects on the G‐6‐PD deficient erythrocytes, in vitro.
Predictive models for human glucose-6-phosphate dehydrogenase deficiency.
TLDR
The present paper has discussed available test systems for determination of the response of G-6-PD-deficient human erythrocytes to environmental agents and the results of research using each model have been presented.
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