Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases

@article{Lee2008LowEP,
  title={Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases},
  author={Kheun Byeol Lee and Jong Soo Lee and Jeen-Woo Park and Tae-lin Huh and You Mie Lee},
  journal={Experimental & Molecular Medicine},
  year={2008},
  volume={40},
  pages={118-129}
}
  • Kheun Byeol Lee, Jong Soo Lee, +2 authors You Mie Lee
  • Published in
    Experimental & Molecular…
    2008
  • Medicine, Biology
  • Proton beam is useful to target tumor tissue sparing normal cells by allowing precise dose only into tumor cells. However, the cellular and molecular mechanisms by which proton beam induces tumor cell death are still undefined. We irradiated three different tumor cells (LLC, HepG2, and Molt-4) with low energy proton beam (35 MeV) with spread out Bragg peak (SOBP) in vitro, and investigated cell death by MTT or CCK-8 assay at 24 h after irradiation. LLC and HepG2 cells were sensitive to proton… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 25 CITATIONS

    Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells.

    VIEW 2 EXCERPTS
    CITES METHODS
    HIGHLY INFLUENCED

    Comparison of Proton and Photon Beam Irradiation in Radiation-Induced Intestinal Injury Using a Mouse Model

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Proton Radiobiology

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES

    Relative biological effectiveness (RBE) values for proton beam therapy.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

    VIEW 11 EXCERPTS
    HIGHLY INFLUENTIAL

    ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

    VIEW 11 EXCERPTS
    HIGHLY INFLUENTIAL

    Oxidative stress and apoptosis: a new treatment paradigm in cancer.

    VIEW 1 EXCERPT