• Corpus ID: 15253235

Low energy pathways for reproducible in vivo protein folding

@article{Cruzeiro2011LowEP,
  title={Low energy pathways for reproducible in vivo protein folding},
  author={Leonor Cruzeiro},
  journal={arXiv: Biological Physics},
  year={2011}
}
  • L. Cruzeiro
  • Published 3 January 2011
  • Biology, Chemistry
  • arXiv: Biological Physics
Two proteins, one belonging to the mainly alpha class and the other belonging to the alpha/beta class, are selected to test a kinetic mechanism for protein folding. Targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a alpha-helical conformation. The results show that for both proteins the alpha-helical initial conformation provides overall lower energy pathways to the native state… 

Figures and Tables from this paper

References

SHOWING 1-10 OF 43 REFERENCES
Protein folding.
TLDR
This study shows that not only is the amino acids in a protein important but also the order in which they are sequenced, which will determine what the secondary and tertiary structure of the protein will be.
Protein folding
TLDR
The importance of protein folding in the biosynthesis of proteins is reviewed and the role of unfolded proteins in this biosynthesis is reviewed.
"J."
however (for it was the literal soul of the life of the Redeemer, John xv. io), is the peculiar token of fellowship with the Redeemer. That love to God (what is meant here is not God’s love to men)
Biochemistry
  • F. Young
  • Education
    The Indian Medical Gazette
  • 1955
The Department of Biochemistry is internationally recognized for its research and education and offers a world-class interdisciplinary research environment in a beautiful mountain setting. As part of
Ann
Aaron Beck’s cognitive therapy model has been used repeatedly to treat depression and anxiety. The case presented here is a 34-year-old female law student with an adjustment disorder with mixed
Proteins: Struct
  • Funct. and Gen. 39, 252
  • 2000
Graphics 14
  • 33
  • 1996
Prot
  • Sci. 18, 2003
  • 2009
J. Computat. Chem
  • J. Computat. Chem
  • 2009
The putative embrio (see text) built from the native fold of the α/β 1IGD protein by substituting the native β-sheets by α-helices. This figure was made with the software VMD
  • The putative embrio (see text) built from the native fold of the α/β 1IGD protein by substituting the native β-sheets by α-helices. This figure was made with the software VMD
...
...