Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake

  title={Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake},
  author={Denise M. Tomkins and Guy A Higgins and Edward Sellers},
Previous work has reported that the 5-hydroxytryptamine (5-HT)1A agonist, 8-hydroxy 2-(di-n-propylamino)tetralin (8-OH DPAT), reduces ethanol intake by rats. However, as 8-OH DPAT reduces 5-HT neurotransmission, these findings are inconsistent with the proposed inhibitory role of central 5-HT neurons on ethanol intake. We examined the effect of 8-OH DPAT on ethanol, water and food intake in rats maintained on a limited access schedule using a lower dose range (6–250 µg/kg) and by assessing… 

The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats

Yohimbine's actions on 5-HT1A receptors contribute to its effects on both alcohol self-administration and reinstatement, suggesting that alpha-2 antagonist properties of yOHimbine may play a role in the reinstatement of alcohol-seeking, but not self-Administration.

Effect of the 5-HT3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure

The present study shows that the reduction in ethanol intake induced by ondansetron was maintained even after a prolonged period of treatment and is not due to an alteration in the absorption or metabolism of ethanol.

5-HT1A agonists: alcohol drinking in rats and squirrel monkeys

The hypothesis that in rats, 5-HT1A receptor stimulation activates somatodendritic receptors at lower doses and postsynaptic receptors at higher doses, each with opposite effects on alcohol intake is supported.

Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats

The present results provide additional support for the hypothesis that brain 5-HT systems are involved in stress-induced reinstatement of alcohol seeking, and the neuronal mechanisms that potentially mediate the unexpected observation that both stimulation of 5- HT release and blockade of5-HT3 receptors attenuate footshock- induced reinstatement are discussed.

5-HT1A receptor agonists: recent developments and controversial issues

  • J. Vry
  • Biology, Psychology
  • 2005
Most evidence points towards a critical involvement of presynaptic receptors in the anxiolytic effects of 5-HT1A receptor agonists (although a possible contribution of postsynaptic receptors cannot be excluded) and a case can be made for the reverse; i.e., a strong involvement of post Synaptic receptors and a questionable contribution of presyaptic receptors.

Cannabinoid–serotonin interactions in alcohol‐preferring vs. alcohol‐avoiding mice

Results show that cannabinoid neurotransmission can exert a permissive control on alcohol intake, possibly through CB1–5–HT1A interactions, however, the differences between C57BL/6’J and DBA/2 J mice indicate that such modulations of alcohol intake are under genetic control.

Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats

Results indicate that activation of alpha-2 adrencoceptor agonists is involved in both stress-induced reinstatement of alcohol seeking and alcohol self-administration, and should be considered in the treatment of alcohol dependence.

Ethanol consumption and serotonin‐1A (5‐HT1A) receptor function in heterozygous BDNF (+/–) mice

5‐HT1A receptor number was not different between genotypes in any area of brain examined, suggesting that 5‐HT 1A receptor function, specifically the capacity of the 5‐ HT1A receptors to activate G proteins, is attenuated in BDNF (+/–) mice.



Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat

Microstructural analysis of the elicited feeding behaviour revealed that the rate of eating after 8-OH-DPAT treatment was very similar to that previously reported following 16 h food deprivation, which appears paradoxical, since drugs which enhance brain serotonergic activity usually inhibit feeding.

8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons.

Effects of the 5-HT receptor agonist, 8-OH-DPAT, on ethanol preference in the rat.

5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward

The facilitatory effect of low-dose 8-OH-DPAT seems most plausibly interpreted in terms of enhanced dopaminergic transmission, which could be brought about by 5HT1A autoreceptor-mediated inhibition of 5-HT release and consequent disinhibition of dopamine transmission.